GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function

FACHIM, Helene A, LOUREIRO, Camila M, CORSI-ZUELLI, Fabiana, SHUHAMA, Rosana, LOUZADA-JUNIOR, Paulo, MENEZES, Paulo Rossi, DALTON, Caroline, DEL-BEN, Cristina Marta and REYNOLDS, Gavin P (2019). GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, 11 (4), 401-410.

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Official URL: https://www.futuremedicine.com/doi/abs/10.2217/epi...
Link to published version:: https://doi.org/10.2217/epi-2018-0127
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    Abstract

    Aim: We investigated GRIN1 and GRIN2B promoter methylation in first-episode schizophrenia patients compared with siblings and controls, testing for correlations between DNA methylation, cognitive performance and clinical variables. Materials & methods: Blood-derived DNA from all groups underwent bisulfite conversion and pyrosequencing to determine methylation at CpG sites within the GRIN1 and GRIN2B promoters and results were compared with the measure of global methylation LINE-1.Results: We found hypomethylation among all CpGs analyzed within GRIN2B promoter in patients and greater LINE-1 methylation in patients and siblings. CpG4 was correlated to a measure of intellectual function. Conclusion: Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia.

    Item Type: Article
    Additional Information: ** From Crossref via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: published 20-02-2019
    Uncontrolled Keywords: Genetics, Cancer Research
    Identification Number: https://doi.org/10.2217/epi-2018-0127
    Page Range: 401-410
    SWORD Depositor: Louise Beirne
    Depositing User: Louise Beirne
    Date Deposited: 01 Mar 2019 09:27
    Last Modified: 07 Mar 2019 09:02
    URI: http://shura.shu.ac.uk/id/eprint/24148

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