Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects

GREEN, Amy, KAUL, Arun, O’SHEA, Jacinta, SHARMA, Ekta, BENNETT, Lisa, MULLINGS, Emma L, MUNAFÒ, Marcus R., NUTT, David J., MELICHAR, Jan K. and DONALDSON, Lucy F. (2013). Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects. Journal of Psychopharmacology, 27 (3), 265-275.

Full text not available from this repository.
Official URL: https://journals.sagepub.com/doi/abs/10.1177/02698...
Link to published version:: https://doi.org/10.1177/0269881112472567
Related URLs:

    Abstract

    Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design. Seven opiate users received methadone and seven buprenorphine maintenance. Six detoxified subjects received naltrexone. Sucrose recognition thresholds and measurements of pleasantness and intensity were determined before and four hours after 1) a single dose of methadone or buprenorphine or 2) naltrexone. Control data were taken from a cohort of healthy volunteers including smokers. All measures of sweet and salt taste perception were significantly greater in opiate users and recently detoxified subjects compared to control subjects, with the exception of sweet pleasantness, which returned to control level after detoxification. Acute methadone administration reduced salt thresholds and unpleasantness to control levels. Increased sweet thresholds and salt unpleasantness in detoxified subjects were reversed by acute opioid antagonism, returning to control levels. These results suggest that opiate use and antagonism alters taste perception. Some of the alterations reverse on detoxification (sweet pleasantness), and others can be reversed by opioid antagonism (sweet threshold, salt unpleasantness). Changes in taste perception may underlie altered consumption of refined sugars in opiate users.

    Item Type: Article
    Uncontrolled Keywords: 11 Medical And Health Sciences; 17 Psychology And Cognitive Sciences; Psychiatry
    Identification Number: https://doi.org/10.1177/0269881112472567
    Page Range: 265-275
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 08 Jan 2019 13:12
    Last Modified: 08 Jan 2019 13:12
    URI: http://shura.shu.ac.uk/id/eprint/23497

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics