Obesity-induced hypertension: brain signaling pathways

DO CARMO, JM, DA SILVA, AA, WANG, Z, FANG, T, ABERDEIN, Nicola, DE LARA RODRIGUEZ, CEP and HALL, JE (2016). Obesity-induced hypertension: brain signaling pathways. Current Hypertension Reports, 18, p. 58.

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Abstract

Obesity greatly increases the risk for cardiovascular, metabolic, and renal diseases and is one of the most significant and preventable causes of increased blood pressure (BP) in patients with essential hypertension. This review highlights recent advances in our understanding of central nervous system (CNS) signaling pathways that contribute to the etiology and pathogenesis of obesity-induced hypertension. We discuss the role of excess adiposity and activation of the brain leptin-melanocortin system in causing increased sympathetic activity in obesity. In addition, we highlight other potential brain mechanisms by which increased weight gain modulates metabolic and cardiovascular functions. Unraveling the CNS mechanisms responsible for increased sympathetic activation and hypertension and how circulating hormones activate brain signaling pathways to control BP offer potentially important therapeutic targets for obesity and hypertension.

Item Type:	Article
Uncontrolled Keywords:	Blood pressure; Leptin; Melanocortins; Sympathetic nervous system; Metabolism; Blood pressure; Leptin; Melanocortins; Metabolism; Sympathetic nervous system; Animals; Brain; Central Nervous System; Humans; Hypertension; Obesity; Signal Transduction; Sleep Apnea Syndromes; Central Nervous System; Brain; Animals; Humans; Sleep Apnea Syndromes; Hypertension; Obesity; Signal Transduction; 1115 Pharmacology And Pharmaceutical Sciences
Identification Number:	https://doi.org/10.1007/s11906-016-0658-1
Page Range:	p. 58
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	01 Apr 2019 13:07
Last Modified:	18 Mar 2021 05:49
URI:	https://shura.shu.ac.uk/id/eprint/23290

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