Role of the brain melanocortins in blood pressure regulation

DO CARMO, J.M., DA SILVA, A.A., WANG, Z., FANG, T., ABERDEIN, Nicola, PEREZ DE LARA, C.E. and HALL, J.E. (2017). Role of the brain melanocortins in blood pressure regulation. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1863 (10), 2508-2514.

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Link to published version:: https://doi.org/10.1016/j.bbadis.2017.03.003

Abstract

© 2017 Elsevier B.V. Melanocortins play an important role in regulating blood pressure (BP) and sympathetic nervous system (SNS) activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals. In experimental models of hypertension with high SNS activity, blockade of the melanocortin-4 receptor (MC4R) reduces BP despite causing marked hyperphagia and obesity. Activation of the central nervous system (CNS) pro-opiomelanocortin (POMC)–MC4R pathway appears to be an important link between obesity, SNS activation and hypertension. Despite having severe obesity, subjects with MC4R deficiency exhibit reductions in BP, heart rate, and urinary catecholamine excretion, as well as attenuated SNS responses to cold stimuli compared to obese subjects with normal MC4R function. In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. We also highlight potential mechanisms and brain circuitry by which the melanocortin system regulates cardiovascular function.

Item Type: Article
Uncontrolled Keywords: Hypertension; Sympathetic activity; Obesity; Pro-opiomelanocortin; Melanocortin-4 receptor; Hypertension; Melanocortin-4 receptor; Obesity; Pro-opiomelanocortin; Sympathetic activity; 0601 Biochemistry And Cell Biology; 1101 Medical Biochemistry And Metabolomics; 1103 Clinical Sciences; Biochemistry & Molecular Biology
Identification Number: https://doi.org/10.1016/j.bbadis.2017.03.003
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 01 Mar 2019 12:03
Last Modified: 04 Mar 2019 13:31
URI: http://shura.shu.ac.uk/id/eprint/23288

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