Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis

LAWSON, Kim (2018). Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis. World Journal of Pharmacology, 7 (1), 1-9.

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Fibromyalgia is characterized by the primary symptoms of persistent diffuse pain, fatigue, sleep disturbance and cognitive dysfunction. Persistent pain conditions, such as fibromyalgia, are often refractory to current available therapies. An involvement of K+ channels in the pathophysiology of fibromyalgia is emerging and supported by drug treatments for this condition exhibiting action at these molecular processes. K+ channels constitute potential novel target candidates for pain therapy offering peripheral and/or central actions. The Kv7 channel activators, flupirtine and retigabine, have exhibited pharmacological profiles compatible to the requirements needed for use as a therapeutic approach to fibromyalgia. Clinical trials to address the multidimensional challenges of fibromyalgia with flupirtine and retigabine will provide important insight to the role of K+ channels in this condition.

Item Type: Article
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Departments - Does NOT include content added after October 2018: Health and Well-being > Department of Bioscience
Identification Number: https://doi.org/10.5497/wjp.v7.i1.1
Page Range: 1-9
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 29 Oct 2018 10:21
Last Modified: 18 Mar 2021 08:15
URI: https://shura.shu.ac.uk/id/eprint/23123

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