Dosimetric evaluation and systematic review of radiation therapy techniques for early stage node-negative breast cancer treatment

CHAN, Tabitha Y, TANG, Johann I, TAN, Poh Wee and ROBERTS, Neill (2018). Dosimetric evaluation and systematic review of radiation therapy techniques for early stage node-negative breast cancer treatment. Cancer Management and Research, 2018 (10), 4853-4870.

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Abstract

Radiation therapy (RT) is essential in treating women with early stage breast cancer. Early stage node-negative breast cancer (ESNNBC) offers a good prognosis; hence, late effects of breast RT becomes increasingly important. Recent literature suggests a potential for an increase in cardiac and pulmonary events after RT. However, these studies have not taken into account the impact of newer and current RT techniques that are now available. Hence, this review aimed to evaluate the clinical evidence for each technique and determine the optimal radiation technique for ESNNBC treatment. Currently, six RT techniques are consistently used and studied: 1) prone positioning, 2) proton beam RT, 3) intensity-modulated RT, 4) breathhold, 5) partial breast irradiation, and 6) intraoperative RT. These techniques show dosimetric promise. However, limited data on late cardiac and pulmonary events exist due to challenges in long-term follow-up. Moving forward, future studies are needed to validate the efficacy and clinical outcomes of these current techniques.

Item Type:	Article
Uncontrolled Keywords:	1112 Oncology And Carcinogenesis
Departments - Does NOT include content added after October 2018:	Health and Well-being > Department of Allied Health Professions
Identification Number:	https://doi.org/10.2147/CMAR.S172818
Page Range:	4853-4870
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	29 Oct 2018 14:38
Last Modified:	18 Mar 2021 07:07
URI:	https://shura.shu.ac.uk/id/eprint/23067

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