Imaging mass spectrometry for the assessment of drugs and metabolites in tissue

TRIM, P. J., FRANCESE, S. and CLENCH, M. R. (2009). Imaging mass spectrometry for the assessment of drugs and metabolites in tissue. Bioanalysis, 1 (2), 309-319.

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Abstract

The study of drug distribution within biological tissue is a key part of the development of new pharmaceuticals. Matrix-assisted laser desorption ionization–mass spectrometric imaging is a powerful new imaging technique that can be used to study the distribution of a diverse range of endogenous and xenobiotic compounds within biological tissue. Here, fundamental aspects of the technique, appropriate instrumentation and applications in the study of xenobiotics and metabolite distribution are described. Sample preparation issues and some of the challenges in data interpretation/handling are also discussed.

Item Type:	Article
Research Institute, Centre or Group:	Biomedical Research Centre
Identification Number:	10.4155/BIO.09.33
Depositing User:	Sarah Ward
Date Deposited:	19 May 2010 11:20
Last Modified:	19 May 2010 11:20
URI:	http://shura.shu.ac.uk/id/eprint/2100

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