Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia

FACHIM, Helene, SRISAWAT, Umarat, DALTON, Caroline and REYNOLDS, Gavin (2018). Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia. Epigenomics. (In Press)

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Link to published version:: 10.2217/epi-2017-0159

Abstract

Deficits of brain parvalbumin (PV) are a consistent finding in schizophrenia and models of psychosis. We investigated whether this is associated with abnormal PV gene (PVALB) methylation in the brain in schizophrenia. Bisulfite pyrosequencing was used to determine cytosine (CpG) methylation in a PVALB promoter sequence. Greater PVALB methylation was found in schizophrenia hippocampus, while no differences were observed in prefrontal cortex. LINE-1 methylation, a measure of global methylation, was also elevated in both regions in schizophrenia, although the PVALB change was independent of this effect. These results provide the first evidence that PVALB promoter methylation is abnormal in schizophrenia and suggest that this epigenetic finding may relate to the reduction of PV expression seen in the disease.

Item Type: Article
Additional Information: ** From Crossref via Jisc Publications Router.
Uncontrolled Keywords: Genetics, Cancer Research
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.2217/epi-2017-0159
SWORD Depositor: Margaret Boot
Depositing User: Margaret Boot
Date Deposited: 30 Apr 2018 13:54
Last Modified: 04 May 2018 10:27
URI: http://shura.shu.ac.uk/id/eprint/20991

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