Tools
Tools
SHEPPARD, Emily C, MORRISH, Rikke Brandstrup, DILLON, Michael J, LEYLAND, Rebecca and CHAHWAN, Richard (2018). Epigenomic modifications mediating antibody maturation. Frontiers in immunology, 9, p. 355.
|
PDF
Leyland-EpigenomicModificationsMediatingAntibodyMaturation(VoR).pdf - Published Version Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Epigenetic modifications, such as histone modifications, DNA methylation status, and non-coding RNAs (ncRNA), all contribute to antibody maturation during somatic hypermutation (SHM) and class-switch recombination (CSR). Histone modifications alter the chromatin landscape and, together with DNA primary and tertiary structures, they help recruit Activation-Induced Cytidine Deaminase (AID) to the immunoglobulin (Ig) locus. AID is a potent DNA mutator, which catalyzes cytosine-to-uracil deamination on single-stranded DNA to create U:G mismatches. It has been shown that alternate chromatin modifications, in concert with ncRNAs and potentially DNA methylation, regulate AID recruitment and stabilize DNA repair factors. We, hereby, assess the combination of these distinct modifications and discuss how they contribute to initiating differential DNA repair pathways at the Ig locus, which ultimately leads to enhanced antibody-antigen binding affinity (SHM) or antibody isotype switching (CSR). We will also highlight how misregulation of epigenomic regulation during DNA repair can compromise antibody development and lead to a number of immunological syndromes and cancer.
| Item Type: | Article |
|---|---|
| Additional Information: | ** From PubMed via Jisc Publications Router. ** History: received 27-11-2017; accepted 08-02-2018. |
| Uncontrolled Keywords: | B cell maturation, antibody diversity, class-switch recombination, cytosine deamination, epigenetic modifications, epigenomics and epigenetics, somatic hypermutation |
| Departments - Does NOT include content added after October 2018: | Health and Well-being > Department of Bioscience |
| Identification Number: | https://doi.org/10.3389/fimmu.2018.00355 |
| Page Range: | p. 355 |
| SWORD Depositor: | Margaret Boot |
| Depositing User: | Margaret Boot |
| Date Deposited: | 27 Mar 2018 09:13 |
| Last Modified: | 18 Mar 2021 01:16 |
| URI: | https://shura.shu.ac.uk/id/eprint/19026 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year