Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke

LIU, Hanxiang, REYNOLDS, Gavin, WANG, Wenmin and WEI, Xianwen (2018). Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39 (6), 1117-1119.

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Official URL: https://link.springer.com/article/10.1007%2Fs10072...
Link to published version:: 10.1007/s10072-018-3307-4

Abstract

Uric acid has neuroprotective properties in experimental and clinical studies of neurodegenerative disease. It is, however, associated with increased risk of stroke, yet, despite some inconsistent findings, increasing evidence suggests it may also be related to improved stroke outcomes. We have determined whether there is an effect of plasma uric acid on the short-term outcome of stroke patients in a general hospital setting using the modified Rankin Scale (mRS). We also investigated the relationship of uric acid with other clinical correlates. Plasma uric acid was determined in 108 acute ischemic stroke patients and their mRS scores measured. Patients with a poor outcome (mRS > 2) had significantly lower uric acid than those with a better outcome; this remained after correcting for the effect of sex on uric acid concentrations. There was no significant association with other epidemiological factors or with cognitive function determined by Mini-Mental State Examination. An association between uric acid and the cerebral circulation was also found in which lower uric acid occurs with posterior artery involvement. These findings demonstrate in a naturalistic cohort of patients the association of uric acid with short-term disability following ischemic stroke. They also raise the question of whether uric acid may influence the regional brain involvement in stroke.

Item Type: Article
Additional Information: ** From PubMed via Jisc Publications Router. ** History: received 13-12-2017; accepted 26-02-2018.
Uncontrolled Keywords: MMSE, Modified Rankin Scale, Neuroprotection, Stroke, Uric acid
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1007/s10072-018-3307-4
SWORD Depositor: Margaret Boot
Depositing User: Margaret Boot
Date Deposited: 27 Mar 2018 08:48
Last Modified: 11 Jun 2018 07:41
URI: http://shura.shu.ac.uk/id/eprint/18969

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