Subcellular distribution of tail-anchored proteins in Arabidopsis

KRIECHBAUMER, Verena, SHAW, Rowena, MUKHERJEE, Joy, BOWSHER, Caroline G., HARRISON, Anne-Marie and ABELL, Benjamin (2009). Subcellular distribution of tail-anchored proteins in Arabidopsis. Traffic, 10 (12), 1753-1764.

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Tail-anchored (TA) proteins function in key cellular processes in eukaryotic cells, such as vesicle trafficking, protein translocation and regulation of transcription. They anchor to internal cell membranes by a C-terminal transmembrane domain, which also serves as a targeting sequence. Targeting occurs post-translationally, via pathways that are specific to the precursor, which makes TA proteins a model system for investigating post-translational protein targeting. Bioinformatics approaches have previously been used to identify potential TA proteins in yeast and humans, yet little is known about TA proteins in plants. The identification of plant TA proteins is important for extending the post-translational model system to plastids, in addition to general proteome characterization, and the identification of functional homologues characterized in other organisms. We identified 454 loci that potentially encode TA proteins in Arabidopsis, and combined published data with new localization experiments to assign localizations to 130 proteins, including 29 associated with plastids. By analysing the tail anchor sequences of characterized proteins, we have developed a tool for predicting localization and estimate that 138 TA proteins are localized to plastids.

Item Type: Article
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Identification Number:
Page Range: 1753-1764
Depositing User: Users 4 not found.
Date Deposited: 12 May 2010 09:22
Last Modified: 18 Mar 2021 21:15

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