High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4- iodoaniline

DUCKETT, Catherine, WILSON, Ian, WALKER, Heather, ABOU-SHAKRA, Fadi, LINDON, John and NICHOLSON, Jeremy (2003). High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4- iodoaniline. Rapid Communications in Mass Spectrometry, 17 (16), 1855-1858.

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Abstract

High-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) provided a rapid and specific means for profiling the iodine-containing metabolites produced by the earthworm Eisenia veneta following exposure to 2-fluoro-4-iodoaniline. Profiles were obtained, using gradient reversed-phase HPLC, from extracts of whole earthworms and from coleomic fluid with as little as 25 ng/peak of iodine detected. The use of ICPMS in this way provides a convenient means of determining the metabolic fate of iodinated compounds without the need for radiolabelled compounds.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Departments - Does NOT include content added after October 2018:	Health and Well-being > Department of Bioscience
Identification Number:	https://doi.org/10.1002/rcm.1125
Page Range:	1855-1858
Depositing User:	Catherine Duckett
Date Deposited:	17 Jan 2018 14:58
Last Modified:	18 Mar 2021 16:31
URI:	https://shura.shu.ac.uk/id/eprint/18193

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