High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4- iodoaniline

DUCKETT, Catherine, WILSON, Ian, WALKER, Heather, ABOU-SHAKRA, Fadi, LINDON, John and NICHOLSON, Jeremy (2003). High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4- iodoaniline. Rapid Communications in Mass Spectrometry, 17 (16), 1855-1858.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/rcm.112...
Link to published version:: 10.1002/rcm.1125

Abstract

High-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) provided a rapid and specific means for profiling the iodine-containing metabolites produced by the earthworm Eisenia veneta following exposure to 2-fluoro-4-iodoaniline. Profiles were obtained, using gradient reversed-phase HPLC, from extracts of whole earthworms and from coleomic fluid with as little as 25 ng/peak of iodine detected. The use of ICPMS in this way provides a convenient means of determining the metabolic fate of iodinated compounds without the need for radiolabelled compounds.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Departments: Health and Well-being > Bioscience
Identification Number: 10.1002/rcm.1125
Depositing User: Catherine Duckett
Date Deposited: 17 Jan 2018 14:58
Last Modified: 17 Jan 2018 14:58
URI: http://shura.shu.ac.uk/id/eprint/18193

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