TEW, Garry A., GUMBER, Anil, MCINTOSH, Emma, KESTERTON, Sue, KING, Brenda, MICHAELS, Jonathan A. and KLONIZAKIS, Markos (2017). Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers. European Journal of Applied Physiology, 118 (2), 321-329.
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Abstract
Purpose: To investigate the effects of a 12-week supervised exercise programme on lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration. Methods: Thirty-eight adults with unilateral venous ulceration who were being treated with lower-limb compression therapy (58% male; mean age 65 years; median ulcer size 5 cm2) were randomly allocated to exercise or control groups. Exercise participants (n=18) were invited to attend thrice weekly sessions of lower-limb aerobic and resistance exercise for 12 weeks. Cutaneous microvascular reactivity was assessed in the gaiter region of ulcerated and non-ulcerated legs at baseline and 3 months using laser Doppler fluxmetry coupled with iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP). Cutaneous vascular conductance (CVC) was calculated as laser Doppler flux (AU)/mean arterial pressure (mmHg). Results: Thirty-seven participants completed follow-up assessments. Median class attendance was 36 (range 2 to 36). Analyses of covariance revealed greater peak CVC responses to ACh in the exercise group at 3 months in both the ulcerated (adjusted difference = 0.944 AU/mmHg; 95% CI 0.504 to 1.384) and non-ulcerated (adjusted difference = 0.596 AU/mmHg; 95% CI 0.028 to 1.164) legs. Peak CVC responses to SNP were also greater in the exercise group at 3 months in the ulcerated leg (adjusted difference = 0.882 AU/mmHg; 95% CI 0.274 to 1.491), but not the non-ulcerated leg (adjusted difference = 0.392 AU/mmHg; 95% CI -0.377 to 1.161). Conclusion: Supervised exercise training improves lower-limb cutaneous microvascular reactivity in adults with venous leg ulceration. Keywords Randomized controlled trial; Exercise; Ulceration; Vascular function; Laser Doppler fluxmetry; Iontophoresis
Item Type: | Article |
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Research Institute, Centre or Group - Does NOT include content added after October 2018: | Centre for Sport and Exercise Science |
Identification Number: | https://doi.org/10.1007/s00421-017-3772-0 |
Page Range: | 321-329 |
Depositing User: | Amanda Keeling |
Date Deposited: | 08 Dec 2017 15:54 |
Last Modified: | 18 Mar 2021 01:23 |
URI: | https://shura.shu.ac.uk/id/eprint/17559 |
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