The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis

LEESE, Elizabeth, CLENCH, Malcolm, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2017). The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis. Toxics, 5 (2), p. 12.

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Official URL: http://www.mdpi.com/2305-6304/5/2/12
Link to published version:: 10.3390/toxics5020012

Abstract

This study investigates the identity of two unexpected arsenic species found separately in a number of urine samples sent to the Health and Safety Executive's Health and Safety Laboratory for arsenic speciation (arsenobetaine, AB; arsenite, As3+; arsenate, As5+; monomethylarsonic acid, MMA5+; and dimethylarsinic acid, DMA5+). Micro liquid chromatography coupled to inductively coupled plasma mass spectrometry (μLC-ICP-MS) and electrospray time of flight tandem mass spectrometry (ESI-QqTOF-MS/MS) were used to identify the two arsenic peaks by comparison to several characterized arsenicals: arsenocholine, AC; trimethyl arsine oxide, TMAO; dimethylarsenoacetate, DMAA; dimethylarsenoethanol, DMAE; thio-dimethylarsinate, thio-DMA; thio-dimethylarsenoacetate, thio-DMAA and thio-dimethylarsenoethanol, thio-DMAE. The results from both the ICP-MS and ESI-QqTOF-MS/MS investigations indicate that the unexpected arsenic species termed peak 1 was thio-DMA. While the unexpected arsenic species termed peak 2 has yet to be identified, this investigation shows that it was not AC, TMAO, DMAA, DMAE, thio-DMA, thio-DMAA or thio-DMAE. This study demonstrates the incidence of unexpected arsenic species in both routine and non-routine urine samples from both workers and hospital patients.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.3390/toxics5020012
Depositing User: Margaret Boot
Date Deposited: 11 Oct 2017 10:23
Last Modified: 11 Oct 2017 19:19
URI: http://shura.shu.ac.uk/id/eprint/16964

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