SHOLADEMI, Benjamin Ayoola (2017). Identification and reduction of pre-analytical errors in clinical chemistry through expert advice. Doctoral, Sheffield Hallam University.
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BSholademi_2017_DProf_Identificationandreduction_VoR.pdf - Accepted Version
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BSholademi_2017_DProf_Identificationandreduction_VoR.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.
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Abstract
Background: Diagnostics in Clinical chemistry laboratory is a pivotal part of
clinical decision-making but is not exempt from ‘human errors’. Scientific
innovations such as automation and electronic order test requesting have
contributed to substantial improvements in the field of laboratory science, but errors
still occur. One major example of such failing is connected to the prevalence of
errors occurring in pre-analytical phase of the Total Testing Process (TTP). Preanalytical
errors can occur at the time of patient assessment, test order entry, patient
identification, sample collection, sample transport, or sample receipt in the
laboratory. Previous work and clinical insights suggest that most errors in the TTP
are extra-laboratory (i.e. they occur before the samples reach the laboratory for
analysis). Such errors are frequently the results of human mistakes during
phlebotomy practice. Therefore to reduce these errors the pre-analytical phase of
the TTP must be prioritised.
Study objective: To investigate the sources of pre-analytical errors in the TTP,
categorize these errors in order to identify the error prone steps, and evaluate errorreporting
frequencies, with the aim of improving service.
Methods: The first part of the study was a query of the laboratory information
management system (LIMS) for samples rejected due to pre-analytical errors. Data
collection was done retrospectively to cover two periods from 2007-2008 (manual
paper test requesting) and 2012-2013 (after implementation of electronic test
ordering, Anglia-ICE). Pre- and post- implementation Anglia-ICE error data were
transferred to excel spreadsheets and compared by chi-squared test. The
contribution of each error category to total sample error received in the laboratory was also determined. The second part of the study was a questionnaire survey of
pre-analytical procedures to capture the attitudes of phlebotomists towards current
practice in Sheffield Teaching Hospitals NHS Foundation Trust (STH NHS FT).
Results: The results of the first part of the study indicated that of the 416,703
specimens collected pre-Anglia ICE, 2,055 (0.49%) were recorded as errors
compared with 1,616 errors (0.11%) of 903,814 specimens collected post-Anglia
ICE implementation, which represents a 0.31% (p<0.05) absolute error reduction
rate, although more samples were received post-Anglia-ICE. The results of the
second part (questionnaire survey) indicate that recommended procedure for
phlebotomy practice was not strictly followed by a large percentage of the staff
surveyed.
Conclusion: This study is the first inquiry linking venous blood sampling (VBS)
practices in phlebotomy to retrospective LIMS pre-analytical data in a UK NHS
Hospital. The results suggest low compliance by staff with recommended practice,
which may be responsible for the prevalence of certain categories of pre-analytical
errors in the TTP and may also be associated with increased risks to attending
patients. It is suggested that the development of a local guideline for VBS and
compliance to this guideline will improve phlebotomy practice, improve the quality
of sample testing in the clinical chemistry laboratory, reduce pre-analytical errors in
TTP and consequently improve the safety of patients.
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