Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence

VEERASAKUL, Siriluk, WATIKTINKORN, Paritat, THANOI, Samur, DALTON, Caroline, FACHIM, Helene, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2017). Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence. Pharmacogenomics, 18 (14).

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Official URL: https://www.futuremedicine.com/doi/full/10.2217/pg...
Link to published version:: 10.2217/pgs-2016-0188

Abstract

Aim: The parvalbumin (PV)-containing subgroup of GABAergic neurons is particularly affected in schizophrenia and animal models of psychosis, including after methamphetamine (METH) administration. We investigated whether METH dependence and METH-induced psychosis may involve an effect on DNA methylation of the PVALB promoter. Materials & methods: The methylation of a PVALB promoter sequence was determined in 100 METH-dependent and 102 control subjects using pyrosequencing. Results: A significant increase in PVALB methylation was observed in METH dependence and METH-induced psychosis. No significant effect on long interspersed nucleotide element-1 methylation, a measure of global DNA methylation, was observed. Conclusion: These results demonstrate a specific association between elevated PVALB methylation and METH-induced psychosis. This finding may contribute to the GABAergic deficits associated with METH dependence.

Item Type: Article
Additional Information: ** From Crossref via Jisc Publications Router.
Uncontrolled Keywords: Molecular Medicine, Genetics, Pharmacology
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.2217/pgs-2016-0188
SWORD Depositor: Jill Hazard
Depositing User: Jill Hazard
Date Deposited: 30 Aug 2017 10:12
Last Modified: 11 Sep 2017 14:49
URI: http://shura.shu.ac.uk/id/eprint/16612

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