Evaluation of deformed image-based dose calculations for adaptive radiotherapy of nasopharyngeal carcinoma

POON, Miranda, HOLBORN, Catherine, CHENG, Ka Fai, FUNG, Winky Wing Ki and CHIU, George (2017). Evaluation of deformed image-based dose calculations for adaptive radiotherapy of nasopharyngeal carcinoma. Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Link to published version:: 10.1016/j.meddos.2017.06.001

Abstract

The ultimate goal of adaptive radiotherapy (ART) is to deliver truly customized radiation treatments. Currently, the quality of cone-beam computed tomography (CBCT) images is still inferior to that of conventional CT images in contour delineations and dose calculations for replanning purposes. This retrospective study aims to evaluate the dosimetric accuracy of using deformed conventional CT images for dose calculations, in the hope of inferring the feasibility of ART using planning CT (PCT) images that deformed to up-to-date CBCT images for patients with nasopharyngeal carcinoma (NPC). Thirty consecutive patients with NPC who had undergone 1 replan in their radiotherapy treatments were selected. The pretreatment PCT images were deformed to match the mid-treatment PCT images by deformable image registration. The same volumetric modulated arc therapy plan was then calculated on the deformed PCT images. The resulting dose distributions and dose volume histograms of the tumors and organs at risk (OARs) were compared with the original plan. Five dose levels, D98%, D95%, D50%, D5%, and D2%, were recorded for 9 NPC targets. Four dose levels, Dmax, D10%, D50%, and Dmean, were recorded for 15 OARs. The greatest percentage difference in observed dose for D98%, D95%, D50%, D5%, and D2% of the targets were 1.71%, 1.55%, 0.64%, 0.97%, and 1.13%, respectively. The greatest percentage difference in observed dose for Dmax, D10%, D50%, and Dmean of the OARs were -26.51% (left optic nerve), -17.06% (left optic nerve), 56.70% (spinal cord), and 18.97% (spinal cord), respectively. In addition, 29 of 45 (64%) dosimetric end points of the targets showed statistically significant dose differences (p < 0.05) between the original plan and the plan calculated on deformed images. Forty-nine of 60 (82%) dosimetric end points of the OARs also showed statistically significant dose differences (p < 0.05). Dose calculations using deformed PCT images could result in significant dose uncertainties in target volumes and OARs. Larger dose deviations were found in OARs in comparison with target volumes. The spinal cord and optic nerve showed the greatest percentage dose differences and the clinical significance has yet to be determined. Deformable registration error was believed to be the problem causing the dose deviations. Owing to unknown clinical significanceof dose deviation results obtained from this study, a conventional CT scan is still required for replanning in patients with NPC who are experiencing significant anatomical changes during the course of radiation treatment. [Abstract copyright: Copyright © 2017 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.]

Item Type: Article
Additional Information: Presented at the American Society for Radiation Oncology (ASTRO), 56th Annual Meeting, San Francisco, CA, September 17, 2014. ** From PubMed via Jisc Publications Router. ** History: ** received: 20-01-2017 ** revised: 11-06-2017 ** accepted: 14-06-2017
Uncontrolled Keywords: Adaptive radiotherapy, Deformable image registration, Dose calculation, Nasopharyngeal carcinoma, Treatment planning
Identification Number: 10.1016/j.meddos.2017.06.001
SWORD Depositor: Jill Hazard
Depositing User: Jill Hazard
Date Deposited: 17 Aug 2017 09:30
Last Modified: 22 Sep 2017 00:41
URI: http://shura.shu.ac.uk/id/eprint/16561

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