MALDI-MSI of lipids in human skin

HART, Philippa J. and CLENCH, Malcolm R. (2017). MALDI-MSI of lipids in human skin. In: COLE, Laura, (ed.) Imaging mass spectrometry : methods and protocols. Methods in Molecular Biology (1618). New York, Humana Press, 29-36.

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Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is now a well-established technique for imaging analysis of sectioned biological tissues. One of the growing areas of interest is in the analysis of skin. MALDI-MSI can provide a wealth of information from within sections of skin. This includes information on the distribution of pharmaceuticals following topical treatments, through to the examination of the composition of different skin layers and studies of proteomic, lipidomic, and metabolomic responses to disease, wounds, and external stimuli. Here, we describe the handling procedures, preparatory treatment, and mass spectrometry setup required for the MALDI MSI analysis of lipids within human skin samples

Item Type: Book Section
Additional Information: Book series ISSN: 1064-3745
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Identification Number:
Page Range: 29-36
Depositing User: Carmel House
Date Deposited: 18 Jul 2017 14:45
Last Modified: 18 Mar 2021 17:30

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