Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross over study

OGGIONI, C., JAKOVLJEVIC, D.G., KLONIZAKIS, Markos, ASHOR, A.W., RUDDOCK, Alan, RANCHORDAS, Mayur, WILLIAMS, E. and SIERVO, M. (2018). Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross over study. International Journal of Food Sciences and Nutrition, 69 (1), 74-83.

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0963748...
Link to published version:: https://doi.org/10.1080/09637486.2017.1328666

Abstract

Dietary nitrate (〖NO〗_3^-) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-day consumption of beetroot juice compared with placebo on 1) blood pressure (BP) measured in resting conditions and during exercise, 2) cardiac and peripheral vascular function and 3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75y and BMI 20.0-29.9kg/m2 were recruited. Measurement were conducted before and after each 7-day intervention period. Consumption of 〖NO〗_3^- had no effect on resting systolic and diastolic BP. 〖NO〗_3^- consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary 〖NO〗_3^- supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study do not support the short-term benefits of dietary 〖NO〗_3^- supplementation on physiological and biochemical markers of vascular health in older healthy adults. Trial Registration: ISRCTN19064955

Item Type: Article
Research Institute, Centre or Group: Centre for Sport and Exercise Science
Departments: Health and Well-being > Department of Sport
Identification Number: https://doi.org/10.1080/09637486.2017.1328666
Depositing User: Amanda Keeling
Date Deposited: 16 Jun 2017 11:06
Last Modified: 16 Nov 2018 13:51
URI: http://shura.shu.ac.uk/id/eprint/15897

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