Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross over study

OGGIONI, C., JAKOVLJEVIC, D.G., KLONIZAKIS, Markos, ASHOR, A.W., RUDDOCK, Alan, RANCHORDAS, Mayur, WILLIAMS, E. and SIERVO, M. (2017). Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross over study. International Journal of Food Sciences and Nutrition, 69 (1), 74-83.

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0963748...
Link to published version:: https://doi.org/10.1080/09637486.2017.1328666
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    Abstract

    Dietary nitrate (〖NO〗_3^-) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-day consumption of beetroot juice compared with placebo on 1) blood pressure (BP) measured in resting conditions and during exercise, 2) cardiac and peripheral vascular function and 3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75y and BMI 20.0-29.9kg/m2 were recruited. Measurement were conducted before and after each 7-day intervention period. Consumption of 〖NO〗_3^- had no effect on resting systolic and diastolic BP. 〖NO〗_3^- consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary 〖NO〗_3^- supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study do not support the short-term benefits of dietary 〖NO〗_3^- supplementation on physiological and biochemical markers of vascular health in older healthy adults. Trial Registration: ISRCTN19064955

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Centre for Sport and Exercise Science
    Departments - Does NOT include content added after October 2018: Health and Well-being > Department of Sport
    Identification Number: https://doi.org/10.1080/09637486.2017.1328666
    Page Range: 74-83
    Depositing User: Amanda Keeling
    Date Deposited: 16 Jun 2017 11:06
    Last Modified: 19 Jun 2020 11:30
    URI: http://shura.shu.ac.uk/id/eprint/15897

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