Effect of age on cutaneous vasomotor responses during local skin heating

HODGES, Gary J., MALLETTE, Matthew M., TEW, Garry A., SAXTON, John M., MOSS, James, RUDDOCK, Alan D. and KLONIZAKIS, Markos (2017). Effect of age on cutaneous vasomotor responses during local skin heating. Microvascular Research, 112, 47-52.

[img] PDF
Klonizakis effect of age on cutaneous.pdf - Accepted Version
Restricted to Repository staff only until 9 March 2018.

Download (1MB)
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Link to published version:: 10.1016/j.mvr.2017.03.002

Abstract

This study examined the effect of ageing on the low-frequency oscillations (vasomotion) of skin blood flow in response to local heating (LH). Skin blood flow was assessed by laser-Doppler flowmetry on the forearm at rest (33 °C) and in response to LH of the skin to both 42 °C and 44 °C in 14 young (24 ± 1 years) and 14 older (64 ± 1 years) participants. Vasomotion was analyzed using a wavelet transform to investigate power of the frequency intervals associated with endothelial, neural, myogenic, respiratory, and cardiac activities of the laser-Doppler signal. Laser-Doppler flux increased in both groups with LH (both d > 1.8, p < 0.001). Endothelial activity increased in both groups following LH to 42 °C (young d = 1.4, p < 0.001; older d = 1.2, p = 0.005) and 44 °C (young d = 1.4, p = 0.001; older d = 1.5, p = 0.005). Endothelial activity was higher in the young compared to older group during LH to 42 °C (d = 1.4, p = 0.017) and 44 °C (d = 1.5, p = 0.004). In response to LH to 42 °C and 44 °C, neural activity in both groups was decreased (both groups and conditions: d > 1.2, p < 0.001). Myogenic activity increased in the younger group following LH to 44 °C (d = 1, p = 0.042), while in the older group, myogenic activity increased following LH to 42 °C (d = 1.2, p = 0.041) and 44 °C (d = 1.1, p = 0.041). Respiratory and cardiac activities increased in both groups during LH to 42 °C and 44 °C (All: d > 0.9, p < 0.017). There were no differences in wavelet amplitude between younger and older in the neural (d = 0.1, p > 0.7), myogenic (d = 0.3, p > 0.7), respiratory (d = 0.4, p > 0.6), and cardiac (d = 0.1, p > 0.7) frequency intervals. These data indicate that LH increases cutaneous endothelial and myogenic activity, while decreasing neural activity. Furthermore, ageing reduces the increase in cutaneous endothelial activity in response to LH. © 2017

Item Type: Article
Research Institute, Centre or Group: Centre for Sport and Exercise Science
Identification Number: 10.1016/j.mvr.2017.03.002
Depositing User: Carmel House
Date Deposited: 12 Apr 2017 13:41
Last Modified: 20 May 2017 15:53
URI: http://shura.shu.ac.uk/id/eprint/15481

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics