Predicting Breast Cancer Response to Neoadjuvant Chemotherapy Using Pretreatment Diffuse Optical Spectroscopic-Texture Analysis

TRAN, William T., GANGEH, Mehrdad J., SANNACHI, Lakshmanan, CHIN, Lee, WATKINS, Elyse, BRUNI, Silvio G., RASTEGAR, Rashin Fallah, CURPEN, Belinda, TRUDEAU, Maureen, GANDHI, Sonal, YAFFE, Martin, SLODKOWSKA, Elzbieta, CHILDS, Charmaine, SADEGHI-NAINI, Ali and CZARNOTA, Gregory J. (2017). Predicting Breast Cancer Response to Neoadjuvant Chemotherapy Using Pretreatment Diffuse Optical Spectroscopic-Texture Analysis. British journal of cancer, 116 (10), 1329-1339.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28419079
Link to published version:: 10.1038/bjc.2017.97

Abstract

Purpose: Diffuse optical spectroscopy (DOS) has been demonstrated capable of monitoring response to neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC) patients. In this study, we evaluate texture features of pre-treatment DOS functional maps for predicting LABC response to NAC. Methods: LABC patients (n = 37) underwent DOS-breast imaging before starting neoadjuvant chemotherapy. Breast-tissue parametric maps were constructed and texture analyses were performed based on grey level co-occurrence matrices (GLCM) for feature extraction. Ground-truth labels as responders (R) or non-responders (NR) were assigned to patients based on Miller-Payne pathological response criteria. The capability of DOS-textural features computed on volumetric tumour data before the start of treatment (i.e. “pre-treatment”) to predict patient responses to NAC was evaluated using a leave-one-out validation scheme at subject level. Data were analysed using a logistic regression, naïve Bayes, and k-nearest neighbour (k-NN) classifiers. Results: Data indicated that textural characteristics of pre-treatment DOS parametric maps can differentiate between treatment response outcomes. The HbO2-homogeneity resulted in the highest accuracy amongst univariate parameters in predicting response to chemotherapy: sensitivity (%Sn) and specificity (%Sp) were 86.5 and 89.0%, respectively and accuracy was 87.8%. The highest predictors using multivariate (binary) combination features were the Hb-Contrast + HbO2-Homogeneity which resulted in a %Sn/%Sp = 78.0/81.0% and an accuracy of 79.5%. Conclusions: This study demonstrated that pre-treatment tumour DOS-texture features can predict breast cancer response to NAC and potentially guide treatments.

Item Type: Article
Research Institute, Centre or Group: Centre for Health and Social Care Research
Identification Number: 10.1038/bjc.2017.97
Depositing User: Hilary Ridgway
Date Deposited: 22 Mar 2017 09:59
Last Modified: 30 Aug 2017 19:23
URI: http://shura.shu.ac.uk/id/eprint/15429

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