The simultaneous detection of trivalent & hexavalent chromium in exhaled breath condensate: A feasibility study comparing workers and controls

LEESE, Elizabeth, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2016). The simultaneous detection of trivalent & hexavalent chromium in exhaled breath condensate: A feasibility study comparing workers and controls. International Journal of Hygiene and Environmental Health, 220 (2), 415-423.

[img]
Preview
PDF
1-s2.0-S1438463916302620-main.pdf - Published Version
Creative Commons Attribution.

Download (1MB) | Preview
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Link to published version:: https://doi.org/10.1016/j.ijheh.2016.12.003
Related URLs:

    Abstract

    The analytical method outlined in this feasibility study has been used to show that trivalent chromium (Cr(III)) and hexavalent chromium (Cr(VI)) can be detected and measured in exhaled breath condensate (EBC) samples. EBC samples and urine samples were collected from a cohort of 58 workers occupationally exposed to hexavalent chromium compounds and 22 unexposed volunteers (control group). Levels of Cr(III) and Cr(VI) were determined in EBC samples and total chromium levels were determined in urine samples. Pre and post working week samples for both EBC and urine were collected in tandem. Total chromium in urine samples was analysed by inductively coupled plasma mass spectrometry (ICP-MS). Analysis of Cr(III) and Cr(VI) in EBC samples used a hyphenated micro liquid chromatography (μLC) system coupled to an ICP-MS. Separation was achieved using an anion exchange micro-sized column. The results showed that the occupationally exposed workers had significantly higher levels of Cr(III) and Cr(VI) in their EBC samples than the control group, as well as higher levels of total chromium in their urine samples. However, for the exposed workers no significant difference was found between pre and post working week EBC samples for either Cr(III) or Cr(VI). This study has established that Cr(III) and Cr(VI) can simultaneously be detected and measured in 'real' EBC samples and will help in understanding inhalation exposure.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1016/j.ijheh.2016.12.003
    Page Range: 415-423
    Depositing User: Carmel House
    Date Deposited: 19 Jan 2017 14:32
    Last Modified: 18 Mar 2021 00:55
    URI: http://shura.shu.ac.uk/id/eprint/14773

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics