A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel

AL-SAGUR, H, KOMATHI, S, KHAN, M, GUREK, A G and HASSAN, Aseel (2017). A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel. Biosensors & bioelectronics, 92, 638-645.

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Abstract

Herein, we report a scalable synthesis of multifunctional conducting polyacrylic acid (PAA) hydrogel (MFH) integrated with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocyanine (LuPc2) as three dimensional robust matrix for glucose oxidase (GOx) immobilization (PAA-rGO/VS-PANI/LuPc2/GOx-MFH). We have integrated the multicomponents such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as the cross linker and initiator. The LuPc2 was then doped to form multifunctional hydrogel (PAA-rGO/VS-PANI/LuPc2-MFH). Finally, biosensor was fabricated by immobilizing GOx into PAA-rGO/VS-PANI/LuPc2-MFH and subsequently used for electrochemical detection of glucose. The PAA-rGO/VS-PANI/LuPc2/GOx-MFH biosensor exhibited high sensitivity (15.31 μA mM−1 cm−2) for the detection of glucose over a concentration range of 2–12 mM with a low detection limit of 25 µm. The PAA-rGO/VS-PANI/LuPc2-MFH biosensor showed a fast response time (1 s) to the addition of glucose with high storage stability of 3 months. The real sample analysis reveals that PAA-rGO/VS-PANI/LuPc2/GOx-MFH could be effectively used as an electrochemical biosensor in industrial as well clinical diagnosis.

Item Type:	Article
Uncontrolled Keywords:	Polyacrylic acid; Reduced graphene oxide; Polyaniline; Lutetium phthalocyanine; Glucose biosensor; Multifunctional hydrogel
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Materials and Engineering Research Institute > Advanced Coatings and Composites Research Centre > Electronic Materials and Sensors Research Group
Identification Number:	https://doi.org/10.1016/j.bios.2016.10.038
Page Range:	638-645
SWORD Depositor:	Ann Betterton
Depositing User:	Ann Betterton
Date Deposited:	30 Nov 2016 14:24
Last Modified:	18 Mar 2021 07:44
URI:	https://shura.shu.ac.uk/id/eprint/14112

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