Optical biosensing transducer based on silicon waveguide structure coated with polyelectrolyte nano layers

HARON, S., NABOK, A. V. and RAY, A. K. (2003). Optical biosensing transducer based on silicon waveguide structure coated with polyelectrolyte nano layers. In: Conference on Bioengineered and Bioinspired Systems, Maspalomas, Spain, May 19-21, 2003. 100-108.

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Abstract

An optical biosensor based on attenuation of the light intensity during multiple reflections. in a planar waveguide has been developed for water pollution monitoring. The planar waveguide consists of a 190 nm thick silicon nitride (Si3N4) core layer sandwiched between 1.5 mum thick silicon dioxide (SiO2) cladding layers. Composite polyelectrolyte self-assembled membranes containing Cyclotetrachromotropylene (CTCT) as an organic indicator and enzymes, such as Urease or Acetylcholine Esterase (AChE) were deposited on top of silicon nitride core layer within a 4 x 6 mm sensing window. Experimental studies on the light propagation through the planar waveguide show the advantages of this method over conventional UV-visible absorption spectroscopy, It was found that the planar waveguide sensitivity is higher by. several orders of magnitude than that for the UV-visible absorption spectroscopy. The respective enzyme reactions as well as their inhibition by heavy metal ions were studied by monitoring the light intensity in the planar waveguide. Cadmium (Cd2+) and lead (Ph2+,) ions were registered in very low concentrations down to I ppb with the planar waveguide transducer. The enzymes used were inhibited differently by the above pollutants, which is promising for the development of enzyme sensor arrays.

Item Type: Conference or Workshop Item (Paper)
Research Institute, Centre or Group: Materials and Engineering Research Institute > Thin Films Research Centre > Electronic Materials and Sensors Research Group
Depositing User: Ann Betterton
Date Deposited: 20 Apr 2010 17:12
Last Modified: 20 Apr 2010 17:12
URI: http://shura.shu.ac.uk/id/eprint/1395

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