MMR vaccination and pervasive developmental disorders: a case-control study

SMEETH, L., COOK, C., FOMBONNE, E., HEAVEY, L., RODRIGUES, L. C., SMITH, P. G. and HALL, A. J. (2004). MMR vaccination and pervasive developmental disorders: a case-control study. The lancet, 364 (9438), 963-969.

Full text not available from this repository.
Link to published version:: 10.1016/S0140-6736(04)17020-7

Abstract

Background:Concern that measles-mumps-rubella (MMR) vaccination might cause autism has led to a fall in vaccine coverage. We investigated whether MMR vaccination is associated with an increased risk of autism or other pervasive developmental disorders.

Methods: We did a matched case-control study using the UK General Practice Research Database. Cases were people born in 1973 or later who had first recorded diagnosis of pervasive developmental disorder while registered with a contributing general practice between 1987 and 2001. Controls were matched on age, sex, and general practice.

Findings: 1294 cases and 4469 controls were included. 1010 cases (78•1%) had MMR vaccination recorded before diagnosis, compared with 3671 controls (82•1%) before the age at which their matched case was diagnosed. After adjustment for age at joining the database, the odds ratio for association between MMR and pervasive developmental disorder was 0•86 (95% CI 0•68–1•09). Findings were similar when restricted to children with a diagnosis of autism, to those vaccinated with MMR before the third birthday, or to the period before media coverage of the hypothesis linking MMR with autism.

Interpretation: Our findings suggest that MMR vaccination is not associated with an increased risk of pervasive developmental disorders.

Item Type: Article
Research Institute, Centre or Group: Psychology Research Group
Identification Number: 10.1016/S0140-6736(04)17020-7
Depositing User: Ann Betterton
Date Deposited: 19 Nov 2008
Last Modified: 09 Dec 2009 18:22
URI: http://shura.shu.ac.uk/id/eprint/135

Actions (login required)

View Item

Downloads

Downloads per month over past year

View more statistics