Ibuprofen in Prevention of Neurodegenerative Diseases

RAINSFORD, Kim (2015). Ibuprofen in Prevention of Neurodegenerative Diseases. In: RAINSFORD, Kim, (ed.) Ibuprofen: discovery, development and therapeutics. Chichester, Wiley, 547-570.

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Official URL: http://onlinelibrary.wiley.com/book/10.1002/978111...
Link to published version:: https://doi.org/10.1002/9781118743614.ch14
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    Abstract

    Recent observations suggest that ibuprofen use may be associated with reduced risk of Parkinson's disease (PD). Ibuprofen may also have some, albeit unspecific, effects in protection against acute brain injury. A major cause of intellectual loss in old age is senile dementia of the Alzheimer's disease type (SDAT). The slowdown in the progressive increment of delta rhythms in the ibuprofen group is regarded as a sign of contrast against the neurodegenerative process. Non-steroidal anti-inflammatory drugs (NSAIDs), in particular ibuprofen, have been investigated for their potential to modify the known molecular and cellular changes thought to underlie Alzheimer's disease (AD). Increasing dementia occurs with progression of PD and recent investigations suggest that accumulation of amyloid occurs in brains of PD patients. Evidence suggests that in robust studies ibuprofen was associated with a 27% reduction in risk whereas that from any NSAID or aspirin had no effect on developing PD.

    Item Type: Book Section
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1002/9781118743614.ch14
    Page Range: 547-570
    Depositing User: Margaret Boot
    Date Deposited: 16 Aug 2016 12:56
    Last Modified: 16 Aug 2016 12:56
    URI: http://shura.shu.ac.uk/id/eprint/13059

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