BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence

IAMJAN, Sri-arun, THANOI, Samur, WATIKTINKORN, Paritat, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2015). BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence. Pharmacogenomics, 16 (14), 1541-1545.

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AIM: Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population. MATERIALS & METHODS: The rs6265 genotype was determined in 100 male METH-dependent subjects and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay. RESULTS: The rs6265 genotype demonstrated significant differences in distribution between METH-dependent subjects and controls in which the frequency of GG genotype versus A-allele carriers was associated with METH dependence. Moreover, a significant effect of genotype on the occurrence of psychosis was found, with a lower frequency of GG genotype associated with METH-induced psychosis. CONCLUSION: The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
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Depositing User: Margaret Boot
Date Deposited: 15 Aug 2016 08:37
Last Modified: 13 Jun 2017 13:38

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