Mass spectrometry imaging for the proteomic study of clinical tissue

COLE, Laura and CLENCH, Malcolm (2015). Mass spectrometry imaging for the proteomic study of clinical tissue. PROTEOMICS - Clinical Applications, 9 (3-4), 335-341.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/prca.20...
Link to published version:: https://doi.org/10.1002/prca.201400103
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    Abstract

    Over the last decade, MALDI-MS imaging has been used by researchers to explore areas of proteomics, lipidomics and metabolomics in samples of clinical origin for both targeted and global biomarker analysis. Numerous technological advancements in MS and clinical tissue MS imaging have been accomplished; hence, in this article we aim to critically discuss whether MS imaging has now in fact become a true champion of the ‘Omics Era’. In order to assess the potential for it to be routinely used in the clinical setting, it is pertinent to discuss some of its limitations, and to examine how these have been addressed by researchers. The key limitations of the technique we will discuss in this viewpoint article are as follows: sample throughput; relevance to patients, the availability of validated/standardised techniques; and integration with conventional pathology and other medical imaging techniques. Good progress has been made over the last 5 years in overcoming these limitations that had previously restricted the use of this technology in the clinical setting.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1002/prca.201400103
    Page Range: 335-341
    Depositing User: Margaret Boot
    Date Deposited: 22 Jul 2016 08:43
    Last Modified: 13 Jun 2017 13:37
    URI: http://shura.shu.ac.uk/id/eprint/12717

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