Observational study of maternal anthropometry and fetal insulin

SOLTANI, H., BRUCE, C. and FRASER, R. B. (1999). Observational study of maternal anthropometry and fetal insulin. Archives of disease in childhood : fetal and neonatal, 81 (2), F122-F124.

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Official URL: http://fn.bmj.com/content/81/2/F122.abstract?sid=f...

Abstract

Aims- To examine the relation between maternal body fat and fetal metabolism.

Methods- In this observational study, cord blood samples were collected from 60 infants of healthy women for the measurement of insulin and C peptide concentrations. Maternal weight, height, body mass index (BMI) and body composition (skin-fold thickness measurements and bioelectrical impedance) were assessed at 13-15 weeks of gestation. Twenty five of the volunteers agreed to have a 75g oral glucose tolerance test at 28-31 weeks of gestation.

Results- Positive correlations were observed with both cord insulin or C peptide concentrations and maternal early pregnancy BMI (r=0.44, p=0.002 and r=0.33, p=0.008, respectively). There was no significant correlation between cord insulin or C peptide concentrations and birthweight or birth weight centiles.

Conclusion- Maternal BMI could be a predictor of fetal cord insulin concentration.

Item Type: Article
Research Institute, Centre or Group: Centre for Health and Social Care Research
Depositing User: Sarah Ward
Date Deposited: 02 Mar 2010 16:56
Last Modified: 02 Mar 2010 17:00
URI: http://shura.shu.ac.uk/id/eprint/1232

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