Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans

ILLANGASEKERA, Yasitha A., KUMARASIRI, Ranjith P.V., FERNANDO, Devaka J. and DALTON, Caroline (2016). Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans. Obesity Research & Clinical Practice. (In Press)

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Link to published version:: 10.1016/j.orcp.2016.02.003


Objectives: To investigate the association between the fat mass and obesity related(FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313polymorphisms with obesity measures and metabolic parameters in urban and ruraldwelling Sri Lankans.Methods: 535 subjects (60.9% female) from the general adult population (ages18—70 years) representative of both urban (28.4%) and rural areas of residencewere recruited by multi-stage random sampling. Body mass index (BMI), waist cir-cumference (WC) and waist-to-hip ratio (WHR) was obtained by standard methods.DNA extracted from whole blood was genotyped using real-time PCR.Results: The FTO risk genotypes (AA + AT) were associated with higher BMI (p = 0.03)and WC (p = 0.05) measures as well as categorical obesity (BMI ≥27.5 kg m−2defini-tion) (OR 1.69 95% CI 1.11—2.56, p = 0.01). The near MC4R risk genotypes (CC + CT)were associated with greater BMI (p = 0.03) as well as categorical obesity (BMI≥25 kg m−2definition) (OR 1.57 95% CI 1.11—2.22, p = 0.01). In addition the MC4Rrisk genotype carriers (CC + CT) had significantly higher fasting blood sugar (FBS)levels compared to the ‘TT’ genotype carriers independent of BMI (p = 0.05). Urban living was associated with significantly greater BMI values for FTO risk genotypescompared to rural living (p = 0.02).Conclusions: FTO and near MC4R variants are associated with obesity measures in SriLankan populations whilst urban living accentuates the obesogenic effect of the FTOpolymorphism.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1016/j.orcp.2016.02.003
Depositing User: Marguerite Lyons
Date Deposited: 26 May 2016 14:03
Last Modified: 26 May 2016 14:03

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