C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes

PEAKE, N.J., BADER, D.L., VESSILLIER, S., RAMACHANDRAN, M., SALTER, D.M., HOBBS, A.J. and CHOWDHURY, T.T. (2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Biochemical and Biophysical Research Communications, 465 (4), 784-789.

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Official URL: http://ac.els-cdn.com/S0006291X15304770/1-s2.0-S00...
Link to published version:: 10.1016/j.bbrc.2015.08.087


Signals induced by mechanical loading and C-type natriuretic peptide (CNP) represent chondroprotective routes that may potentially prevent osteoarthritis (OA). We examined whether CNP will reduce hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminish pro-inflammatory effects in human chondrocytes. The presence of interleukin-1β (IL-1β) increased HA production and export via MRP5 that was reduced with CNP and/or loading. Treatment with IL-1β conditioned medium increased production of catabolic mediators and the response was reduced with the hyaluronan inhibitor, Pep-1. The induction of pro-inflammatory cytokines by the conditioned medium was reduced by CNP and/or Pep-1, αCD44 or αTLR4 in a cytokine-dependent manner, suggesting that the CNP pathway is protective and should be exploited further.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1016/j.bbrc.2015.08.087
Depositing User: Marguerite Lyons
Date Deposited: 14 Dec 2015 14:29
Last Modified: 25 Apr 2016 15:02
URI: http://shura.shu.ac.uk/id/eprint/10999

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