Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C–H bond insertion

ALLWOOD, Daniel, BLAKEMORE, David C. and LEY, Steven V. (2014). Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C–H bond insertion. Organic Letters, 16 (11), 3064-3067.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol5011714
Link to published version:: 10.1021/ol5011714

Abstract

Preparation of ketones by insertion of diazo compounds into the formyl C−H bond of an aldehyde is an attractive procedure, but use of structurally diverse diazo compounds is hampered by preparation and safety issues. A convenient procedure for the synthesis of unsymmetrical ketones from bench-stable tosylhydrazones and aryl aldehydes is reported. The procedure can be performed in one pot from the parent carbonyl compound and needs only a base, with no additional promoters being required.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1021/ol5011714
Depositing User: Marguerite Lyons
Date Deposited: 13 Aug 2015 09:19
Last Modified: 13 Aug 2015 09:19
URI: http://shura.shu.ac.uk/id/eprint/10760

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