ALLWOOD, Daniel, BLAKEMORE, David C. and LEY, Steven V. (2014). Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C–H bond insertion. Organic Letters, 16 (11), 3064-3067.Full text not available from this repository.
Preparation of ketones by insertion of diazo compounds into the formyl C−H bond of an aldehyde is an attractive procedure, but use of structurally diverse diazo compounds is hampered by preparation and safety issues. A convenient procedure for the synthesis of unsymmetrical ketones from bench-stable tosylhydrazones and aryl aldehydes is reported. The procedure can be performed in one pot from the parent carbonyl compound and needs only a base, with no additional promoters being required.
|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|
|Depositing User:||Marguerite Lyons|
|Date Deposited:||13 Aug 2015 09:19|
|Last Modified:||13 Aug 2015 09:19|
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