Distribution of GABA(B) receptor protein in somatosensory cortex and thalamus of adult rats and during postnatal development.

PRINCIVALLE, A, REGONDI, M C, FRASSONI, C, BOWERY, N G and SPREAFICO, R (2000). Distribution of GABA(B) receptor protein in somatosensory cortex and thalamus of adult rats and during postnatal development. Brain Research Bulletin, 52 (5), 397-405.

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Abstract

In the present study we report the immunolocalisation of gamma-aminobutyric acid (GABA)(B) receptors within the cerebral somatosensory cortex (S1) and thalamus of adult and young (1-22 postnatal days) rats. The antibody used recognises a peptide in the carboxy-terminal domain and therefore did not distinguish between the different isoforms GABA(B)1a or GABA(B)1b. The results showed that GABA(B) receptor protein was widely distributed in the brain of both adult and young rats, with different degrees of labelling in separate cerebral nuclei. Antibody labelling was localised both on cells and the neuropil. In the cerebral cortex of adult animals the highest immunolabelling was evident in layers V and VIb, although immunoreactivity was also present in the superficial layers. The strongest signal was evident in the medial habenula.The thalamus showed labelling in the reticular, ventrobasal and geniculate nuclei. In the first postnatal days GABA(B) expression was evident in the cortical cells of layer V, VIb and in the cortical plate. The pattern of labelling in the cerebral cortex of young rats became indistinguishable from that of adult rats by day 12. In the thalamus, the main difference compared to the adult pattern was observed in the mediodorsal nucleus which, in early development, showed a high immunosignal, however, by postnatal day 22 the immunoreactivity decreased with only some scattered cells labelled in the adult brain.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1016/S0361-9230(00)00256-2
Page Range:	397-405
Depositing User:	Jamie Young
Date Deposited:	03 Jun 2015 08:43
Last Modified:	18 Mar 2021 23:15
URI:	https://shura.shu.ac.uk/id/eprint/9990

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