Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex.

PRINCIVALLE, A, SPREAFICO, R, BOWERY, N and DE CURTIS, M (2000). Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex. The European Journal of Neuroscience, 12 (4), 1516-1520.

Full text not available from this repository.
Link to published version:: https://doi.org/10.1046/j.1460-9568.2000.01060.x

Abstract

A peculiar, layer-segregated immunoreactive distribution of GABABR1a and GABABR1b receptor antibodies is present in the piriform cortex of adult rats. The GABABR1a antibody selectively marked the neuropile in layer Ia, where afferent olfactory fibres and intrinsic GABAergic (gamma-aminobutyric acid) axons terminate on the distal apical dendrites of pyramidal neurons. The GABABR1b antibody was detected in the soma and the large basal dendrites of layer II and III neurons. The pattern of distribution observed supports the hypothesis that (presynaptic) GABABR1a receptors in the superficial molecular layer modulate neurotransmitter release in a feedforward synaptic circuit, whereas GABABR1b (postsynaptic) receptors mediate feedback inhibitory potentials on principal cells.

Item Type: Article
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Identification Number: https://doi.org/10.1046/j.1460-9568.2000.01060.x
Page Range: 1516-1520
Depositing User: Jamie Young
Date Deposited: 03 Jun 2015 08:46
Last Modified: 18 Mar 2021 23:15
URI: https://shura.shu.ac.uk/id/eprint/9989

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics