KHAN, Akram, MILLER, Keith, RAINSFORD, Kim and ZHOU, Yong (2013). Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates. Molecules, 18 (3), 3227-3240.
Full text not available from this repository.Abstract
Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with phosphorous oxychloride to form 4-chloroquinolines, which reacted on heating with diethyl sodiomethylmalonate in DMF to yield moderate yields of substituted ethyl 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.
Item Type: | Article |
---|---|
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.3390/molecules18033227 |
Page Range: | 3227-3240 |
Depositing User: | Users 3084 not found. |
Date Deposited: | 10 Dec 2013 17:07 |
Last Modified: | 18 Mar 2021 19:30 |
URI: | https://shura.shu.ac.uk/id/eprint/7493 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year