CONNER, Matthew, CONNER, Alex C., BROWN, James E. P. and BILL, Roslyn M. (2010). Membrane trafficking of Aquaporin 1 is mediated by Protein Kinase C via microtubules and regulated by tonicity. Biochemistry, 49 (5), 821-823.
Full text not available from this repository.Abstract
It is well-known that the rapid flow of water into and out of cells is controlled by membrane proteins called aquaporins (AQPs). However, the mechanisms that allow cells to quickly respond to a changing osmotic environment are less well established. Using GFP−AQP fusion proteins expressed in HEK293 cells, we demonstrate the reversible manipulation of cellular trafficking of AQP1. AQP1 trafficking was mediated by the tonicity of the cell environment in a specific PKC- and microtubule-dependent manner. This suggests that the increased level of water transport following osmotic change may be due a phosphorylation-dependent increase in the level of AQP1 trafficking resulting in membrane localization.
Item Type: | Article |
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Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1021/bi902068b |
Page Range: | 821-823 |
Depositing User: | Rebecca Jones |
Date Deposited: | 01 Mar 2012 10:09 |
Last Modified: | 18 Mar 2021 10:15 |
URI: | https://shura.shu.ac.uk/id/eprint/4872 |
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