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JOHNSON, Alice, IFFLAND, Linda, SINGH, Kuldip, APFEL, Ulf-Peter and SUNTHARALINGAM, Kogularamanan (2021). A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity. Dalton Trans, 50 (17), 5779-5783.
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Johnson-Dithiacyclam-coordinatedSilver(VoR).pdf - Published Version Creative Commons Attribution Non-commercial. Download (817kB) | Preview |
Official URL: https://pubs.rsc.org/en/content/articlelanding/202...
Open Access URL: https://pubs.rsc.org/en/content/articlepdf/2021/dt...
(Published version)
Link to published version:: https://doi.org/10.1039/d1dt01155c
Abstract
A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cell Line, Tumor; Coordination Complexes; Humans; Neoplastic Stem Cells; Polymers; Reactive Oxygen Species; Silver; Cell Line, Tumor; Humans; Silver; Reactive Oxygen Species; Polymers; Neoplastic Stem Cells; Coordination Complexes; 0302 Inorganic Chemistry; 0307 Theoretical and Computational Chemistry; 0399 Other Chemical Sciences; Inorganic & Nuclear Chemistry |
| Identification Number: | https://doi.org/10.1039/d1dt01155c |
| Page Range: | 5779-5783 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 17 Mar 2022 14:37 |
| Last Modified: | 17 Mar 2022 15:16 |
| URI: | https://shura.shu.ac.uk/id/eprint/29936 |
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