WOOTTON, Timothy and ALLWOOD, Daniel (2022). Synthesis of spirocyclic dihydropyrazoles from tosylhydrazones and electron-deficient alkenes. Organic and Biomolecular Chemistry.
|
PDF
d2ob00093h.pdf - Published Version Creative Commons Attribution. Download (1MB) | Preview |
|
|
PDF
d2ob00093h1.pdf - Supplemental Material Creative Commons Attribution. Download (35MB) | Preview |
Abstract
Spirocycles represent a diverse class of molecules which have received significant attention in the pharmaceutical industry due to their broad biological activities and inherent molecular three-dimensionality. Herein, we demonstrate a procedurally simple method for the preparation of a range of spirocyclic dihydropyrazoles. The protocol utilises bench stable cyclic tosylhydrazones, which are trivial to prepare from the parent cyclic ketone without need for purification, and commercially available electron deficient alkenes. The synthetic utility of the core scaffold is also demonstrated to highlight potential for applications in medicinal chemistry and drug development programmes.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Biomolecular Sciences Research Centre; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; Organic Chemistry |
Identification Number: | https://doi.org/10.1039/d2ob00093h |
SWORD Depositor: | Symplectic Elements |
Depositing User: | Symplectic Elements |
Date Deposited: | 03 Feb 2022 16:05 |
Last Modified: | 15 Mar 2022 09:30 |
URI: | https://shura.shu.ac.uk/id/eprint/29701 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year