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KHANTHIYONG, B, THANOI, S, REYNOLDS, Gavin and NUDMAMUD-THANOI, S (2019). Association study of the functional Catechol-OMethyltranferase (COMT) Val<sup>158</sup>Met polymorphism on executive cognitive function in a Thai sample. International Journal of Medical Sciences, 16 (11), 1461-1465.
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Abstract
Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little work has investigated this in the Thai population and the relationship of age and education with this association remains unclear. Therefore, this study was designed to investigate the association of this polymorphism of the COMT gene with executive cognitive brain function in healthy subjects and the relationship with age and education. The Wisconsin Card Sorting Test (WCST) was performed to assess executive function in 254 healthy Thai subjects (aged 20-72 years). The results showed a significant association of rs4680 with executive function, in which Val/Met heterozygotes demonstrated better cognitive set shifting performance. Moreover, Met allele carriers showed a significantly stronger effect in the categories completed score than did Val homozygotes. Furthermore, age and education also showed a significant association with COMT genotype and WCST. These results revealed that executive cognitive function is associated with COMT genotype and influenced by age and/or education level in a Thai sample.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Catechol-O-Methyltranferase (COMT); Executive function; Single Nucleotide Polymorphism (SNP); Val158Met; Wisconsin Card Sorting Test (WCST); Adult; Aged; Alleles; Asian Continental Ancestry Group; Brain; Catechol O-Methyltransferase; Catechols; Cognition; Dopamine; Executive Function; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; Male; Middle Aged; Young Adult; Brain; Humans; Genetic Predisposition to Disease; Dopamine; Catechols; Catechol O-Methyltransferase; Cognition; Genotype; Heterozygote; Alleles; Adult; Aged; Middle Aged; Asian Continental Ancestry Group; Female; Male; Young Adult; Executive Function; Genetic Association Studies; Gastroenterology & Hepatology; 11 Medical and Health Sciences |
| Identification Number: | https://doi.org/10.7150/ijms.35789 |
| Page Range: | 1461-1465 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 07 Dec 2021 17:57 |
| Last Modified: | 08 Dec 2021 08:00 |
| URI: | https://shura.shu.ac.uk/id/eprint/29205 |
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