REID, M. J., CROSS, A. K., HADDOCK, G., ALLAN, S. M., STOCK, C. J., WOODROOFE, M. N., BUTTLE, D. J. and BUNNING, R. A. D. (2009). ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Neuroscience letters, 452 (3), 252-257.
Full text not available from this repository.Abstract
The ADAMTS enzymes (a disintegrin and metalloproteinase with thrombospondin type 1-like motifs) have important roles in central nervous system (CNS) physiology and pathology. This current study aimed to analyse the expression of ADAMTS-9 following transient middle cerebral artery occlusion (tMCAo) in the rat, a model of focal cerebral ischaemia. Using real-time RT-PCR, ADAMTS-9 mRNA was demonstrated to be significantly up-regulated in tMCAo brain tissue compared to sham-operated at 24 h post-ischaemia. The mature form of the ADAMTS-9 protein was only detected by Western blotting in brains subjected to tMCAo at 24 h. In situ hybridisation demonstrated that ADAMTS-9 mRNA was expressed by neurones in tMCAo tissue. This study indicates that ADAMTS-9 expression is modulated in response to cerebral ischaemia in vivo and further research will resolve whether it plays a role in the subsequent degenerative or repair processes.
Item Type: | Article |
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Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1016/j.neulet.2009.01.058 |
Page Range: | 252-257 |
Depositing User: | Users 4 not found. |
Date Deposited: | 12 May 2010 09:37 |
Last Modified: | 18 Mar 2021 21:15 |
URI: | https://shura.shu.ac.uk/id/eprint/1873 |
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