LEESE, Elizabeth, CLENCH, Malcolm, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2017). The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis. Toxics, 5 (2), p. 12.
|
PDF
Clench-InvestigationofUnexpectedArsenicCompounds(VoR).pdf - Published Version Creative Commons Attribution. Download (1MB) | Preview |
Abstract
This study investigates the identity of two unexpected arsenic species found separately in a number of urine samples sent to the Health and Safety Executive's Health and Safety Laboratory for arsenic speciation (arsenobetaine, AB; arsenite, As3+; arsenate, As5+; monomethylarsonic acid, MMA5+; and dimethylarsinic acid, DMA5+). Micro liquid chromatography coupled to inductively coupled plasma mass spectrometry (μLC-ICP-MS) and electrospray time of flight tandem mass spectrometry (ESI-QqTOF-MS/MS) were used to identify the two arsenic peaks by comparison to several characterized arsenicals: arsenocholine, AC; trimethyl arsine oxide, TMAO; dimethylarsenoacetate, DMAA; dimethylarsenoethanol, DMAE; thio-dimethylarsinate, thio-DMA; thio-dimethylarsenoacetate, thio-DMAA and thio-dimethylarsenoethanol, thio-DMAE. The results from both the ICP-MS and ESI-QqTOF-MS/MS investigations indicate that the unexpected arsenic species termed peak 1 was thio-DMA. While the unexpected arsenic species termed peak 2 has yet to be identified, this investigation shows that it was not AC, TMAO, DMAA, DMAE, thio-DMA, thio-DMAA or thio-DMAE. This study demonstrates the incidence of unexpected arsenic species in both routine and non-routine urine samples from both workers and hospital patients.
Item Type: | Article |
---|---|
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.3390/toxics5020012 |
Page Range: | p. 12 |
Depositing User: | Margaret Boot |
Date Deposited: | 11 Oct 2017 10:23 |
Last Modified: | 18 Mar 2021 15:34 |
URI: | https://shura.shu.ac.uk/id/eprint/16964 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year