Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry

BAILEY, Melanie J., BRADSHAW, Robert, FRANCESE, Simona, SALTER, Tara L., COSTA, Catia, ISMAIL, Mahado, P. WEBB, Roger, BOSMAN, Ingrid, WOLFF, Kim and DE PUIT, Marcel (2015). Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry. Analyst, 140 (18), 6254-6259.

Full text not available from this repository.

Abstract

Latent fingerprints provide a potential route to the secure, high throughput and non-invasive detection of drugs of abuse. In this study we show for the first time that the excreted metabolites of drugs of abuse can be detected in fingerprints using ambient mass spectrometry. Fingerprints and oral fluid were taken from patients attending a drug and alcohol treatment service. Gas chromatography mass spectrometry (GC-MS) was used to test the oral fluid of patients for the presence of cocaine and benzoylecgonine. The corresponding fingerprints were analysed using Desorption Electrospray Ionization (DESI) which operates under ambient conditions and Ion Mobility Tandem Mass Spectrometry Matrix Assisted Laser Desorption Ionization (MALDI-IMS-MS/MS) and Secondary Ion Mass Spectrometry (SIMS). The detection of cocaine, benzoylecgonine (BZE) and methylecgonine (EME) in latent fingerprints using both DESI and MALDI showed good correlation with oral fluid testing. The sensitivity of SIMS was found to be insufficient for this application. These results provide exciting opportunities for the use of fingerprints as a new sampling medium for secure, non-invasive drug detection. The mass spectrometry techniques used here offer a high level of selectivity and consume only a small area of a single fingerprint, allowing repeat and high throughput analyses of a single sample.

Item Type:	Article
Additional Information:	** From Crossref via Jisc Publications Router.
Uncontrolled Keywords:	Analytical Chemistry, Spectroscopy, Electrochemistry, Biochemistry, Environmental Chemistry
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1039/c5an00112a
Page Range:	6254-6259
SWORD Depositor:	Hilary Ridgway
Depositing User:	Hilary Ridgway
Date Deposited:	12 Jul 2017 10:36
Last Modified:	18 Mar 2021 17:30
URI:	https://shura.shu.ac.uk/id/eprint/16194

Actions (login required)

View Item

Downloads

Publication Metrics