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GRIFFIN, Lizzie, COX, Michael and DUCKETT, Catherine (2016). Trace 56Fe, 63/65Cu and 64Zn metal analysis in whole blood by SEC-HPLC-ICPMS. Chromatography Today, 9 (3), 32-34.
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Duckett - Trace 56Fe, 6365 CU and 64 Zn metal analysis in whole blood by.pdf - Published Version All rights reserved. Download (1MB) | Preview |
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Duckett - Trace 56Fe, 6365 CU and 64 Zn metal analysis in whole blood by (AM).pdf - Accepted Version All rights reserved. Download (138kB) | Preview |
Abstract
Trace metals have important biological roles to play within the human body. This work investigated the presence of 56Fe, 63/65Cu and 64Zn in blood and utilised dried blood spot sampling (DBS) technology. Blood was taken from one female subject and extraction conditions were optimised. Extracted samples were analysed by SEC-HPLC for protein separation and SEC-HPLC-ICP-MS for metal detection. Proteins from the blood samples separated via SEC-HPLC were found to be haemoglobin, myoglobin and transferrin; SEC-HPLC-ICPMS metal determination saw correlated peaks of 56Fe, 63/65Cu. However, 64Zn peaks were much weaker and could therefore only be tentatively identified.
| Item Type: | Article |
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| Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
| Departments - Does NOT include content added after October 2018: | Health and Well-being > Department of Bioscience |
| Page Range: | 32-34 |
| Depositing User: | Catherine Duckett |
| Date Deposited: | 06 Dec 2016 12:34 |
| Last Modified: | 18 Mar 2021 00:39 |
| URI: | https://shura.shu.ac.uk/id/eprint/14200 |
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