ROBSON, H., GRUBE, M., GRIFFITHS, T. D., RALPH, M. A. Lambon and SAGE, Karen (2013). Fundamental deficits of auditory perception in Wernicke's aphasia. Cortex, 49 (7), 1808-1822.
Full text not available from this repository.Abstract
Objective: This work investigates the nature of the comprehension impairment in Wernicke's aphasia (WA), by examining the relationship between deficits in auditory processing of fundamental, non-verbal acoustic stimuli and auditory comprehension. WA, a condition resulting in severely disrupted auditory comprehension, primarily occurs following a cerebrovascular accident (CVA) to the left temporo-parietal cortex. Whilst damage to posterior superior temporal areas is associated with auditory linguistic comprehension impairments, functional-imaging indicates that these areas may not be specific to speech processing but part of a network for generic auditory analysis. Methods: We examined analysis of basic acoustic stimuli in WA participants (n = 10) using auditory stimuli reflective of theories of cortical auditory processing and of speech cues. Auditory spectral, temporal and spectro-temporal analysis was assessed using pure-tone frequency discrimination, frequency modulation (FM) detection and the detection of dynamic modulation (DM) in ?moving ripple? stimuli. All tasks used criterion-free, adaptive measures of threshold to ensure reliable results at the individual level. Results: Participants with WA showed normal frequency discrimination but significant impairments in FM and DM detection, relative to age- and hearing-matched controls at the group level (n = 10). At the individual level, there was considerable variation in performance, and thresholds for both FM and DM detection correlated significantly with auditory comprehension abilities in the WA participants. Conclusion: These results demonstrate the co-occurrence of a deficit in fundamental auditory processing of temporal and spectro-temporal non-verbal stimuli in WA, which may have a causal contribution to the auditory language comprehension impairment. Results are discussed in the context of traditional neuropsychology and current models of cortical auditory processing.
Item Type: | Article |
---|---|
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Centre for Health and Social Care Research |
Identification Number: | https://doi.org/10.1016/j.cortex.2012.11.012 |
Page Range: | 1808-1822 |
Depositing User: | Karen Sage |
Date Deposited: | 25 Feb 2016 14:00 |
Last Modified: | 18 Mar 2021 18:16 |
URI: | https://shura.shu.ac.uk/id/eprint/11610 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year