ALLWOOD, Daniel, BLAKEMORE, David C. and LEY, Steven V. (2014). Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C–H bond insertion. Organic Letters, 16 (11), 3064-3067.
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Abstract
Preparation of ketones by insertion of diazo compounds into the formyl C−H bond of an aldehyde is an attractive procedure, but use of structurally diverse diazo compounds is hampered by preparation and safety issues. A convenient procedure for the synthesis of unsymmetrical ketones from bench-stable tosylhydrazones and aryl aldehydes is reported. The procedure can be performed in one pot from the parent carbonyl compound and needs only a base, with no additional promoters being required.
Item Type: | Article |
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Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1021/ol5011714 |
Page Range: | 3064-3067 |
Depositing User: | Users 3084 not found. |
Date Deposited: | 13 Aug 2015 09:19 |
Last Modified: | 17 Mar 2021 20:02 |
URI: | https://shura.shu.ac.uk/id/eprint/10760 |
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