KLONIZAKIS, M., TEW, G., MICHAELS, J. and SAXTON, J. M. (2009). Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients. Microvascular research, 77 (2), 158-162.
Full text not available from this repository.Abstract
Evidence exists that cutaneous microvascular endothelial dysfunction persists in patients following varicose vein surgery. This study compared cutaneous microvascular function between post-surgical varicose vein patients and healthy controls and investigated whether any impairment of function can be attenuated by acute lower-limb exercise. Cutaneous flux responses of the gaiter area were measured in supine and standing positions before and after a 25-min walk using laser Doppler fluximetry and incremental-dose administration of acetylcholine (ACh) and sodium nitroprusside (SNP). The pre-exercise peak responses to ACh (standing) were lower in patients than controls (48 ± 11 vs. 96 ± 28 PU; P = 0.032), whereas treadmill exercise abolished this difference (P = 0.819). In contrast, the pre-exercise responses to SNP (standing) appeared higher in patients than controls (3 mC responses: 24 ± 4 vs. 10 ± 2 PU, respectively; P = 0.023), with no effect of acute exercise (P > 0.05). These findings suggest that acute treadmill exercise augments microvascular endothelial function in post-surgical varicose vein patients to levels observed in age-matched controls.
Item Type: | Article |
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Uncontrolled Keywords: | microcirculation, skin, exercise, venous disease, laser Doppler, endothelial function, UoA26 |
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Centre for Sport and Exercise Science |
Identification Number: | https://doi.org/10.1016/j.mvr.2008.09.009 |
Page Range: | 158-162 |
Depositing User: | Users 4 not found. |
Date Deposited: | 02 Feb 2010 16:41 |
Last Modified: | 18 Mar 2021 23:01 |
URI: | https://shura.shu.ac.uk/id/eprint/1005 |
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